Atrophy of the tongue following complete versus partial hypoglossal nerve transection in a canine model
Identifieur interne : 000090 ( Main/Exploration ); précédent : 000089; suivant : 000091Atrophy of the tongue following complete versus partial hypoglossal nerve transection in a canine model
Auteurs : Kyle J. Chambers [États-Unis] ; Douglas C. Anthony [États-Unis] ; Gregory W. Randolph [États-Unis] ; Christopher J. Hartnick [États-Unis] ; Edward G. Stopa [États-Unis] ; Phillip C. Song [États-Unis]Source :
- The Laryngoscope [ 0023-852X ] ; 2016-12.
English descriptors
- Teeft :
- Anastomosis, Antimyosin heavy chain, Atrophy, Brown university, Canine, Canine model, Complete hypoglossal transection, Complete transection, Connective tissue, Denervated, Denervated side, Denervation, Donor nerve, Facial, Facial reanimation, Hypoglossal, Hypoglossal nerve, Hypoglossal nerve transection, Hypoglossal transection, Intravenous dose, Laboratory animal, Laryngeal, Laryngeal reinnervation, Laryngoscope, Less muscle area, Less severe, Looser connective tissue, Medial, Medial branch, Muscle atrophy, Muscle cell, Muscle fiber, Myosin, Myosin content, Nerve, Nerve anastomosis, Neuromuscular change, Neuromuscular organization, Nondenervated control side, Nondenervated side, Nonoperated side, Optical density, Otolaryngol head neck surg, Pale eosinophilia, Partial hypoglossal nerve transection, Partial transection, Rhode island, Right side, Severe atrophy, Tongue atrophy, Tongue dysfunction, Tongue function, Transection.
Abstract
Objectives/Hypothesis: The hypoglossal nerve (XII) has been used as a donor nerve in facial and laryngeal reinnervation. The purpose of this study was to investigate the neuromuscular changes that occur within the tongue following partial or complete transection of XII using a canine model. Study Design: Histopathological comparison of tongue denervation following two types of XII resection in a canine model. Methods: Ten adult canines underwent complete unilateral resection of XII or resection of only the medial terminal branch of the hypoglossal nerve (mXII). After 6 months of recovery, tongue specimens were analyzed histopathologically using whole cross‐sections. Routine histologic sections were assessed by two neuropathologists blinded to the type of denervation. The cross‐sectional area was calculated of both sides of the tongue, and the amount of myosin was quantified morphometrically using immunohistochemistry for myosin (antimyosin heavy chain, fast isotype). Statistical comparison between partial and complete denervation was performed using the Student t test. Results: Six months following XII transection, quantitative measures of the cross‐sectional area of the tongue and content of myosin demonstrated severe muscle atrophy on the operated side of the tongue for both groups, compared to the nonoperated side. For partial transection involving only mXII, the degree of atrophy was less severe (P < .05). Conclusions: This study provides new histological information demonstrating that partial resection of the hypoglossal nerve, sacrificing only the proximal medial branch of the hypoglossal nerve (mXII), results in less severe atrophy of the tongue than complete transection of the entire hypoglossal nerve. Level of Evidence: NA Laryngoscope, 126:2689–2693, 2016
Url:
DOI: 10.1002/lary.26065
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 002821
- to stream Istex, to step Curation: 002623
- to stream Istex, to step Checkpoint: 000069
- to stream Main, to step Merge: 000090
- to stream Main, to step Curation: 000090
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Atrophy of the tongue following complete versus partial hypoglossal nerve transection in a canine model</title><author><name sortKey="Chambers, Kyle J" sort="Chambers, Kyle J" uniqKey="Chambers K" first="Kyle J." last="Chambers">Kyle J. Chambers</name></author><author><name sortKey="Anthony, Douglas C" sort="Anthony, Douglas C" uniqKey="Anthony D" first="Douglas C." last="Anthony">Douglas C. Anthony</name></author><author><name sortKey="Randolph, Gregory W" sort="Randolph, Gregory W" uniqKey="Randolph G" first="Gregory W." last="Randolph">Gregory W. Randolph</name></author><author><name sortKey="Hartnick, Christopher J" sort="Hartnick, Christopher J" uniqKey="Hartnick C" first="Christopher J." last="Hartnick">Christopher J. Hartnick</name></author><author><name sortKey="Stopa, Edward G" sort="Stopa, Edward G" uniqKey="Stopa E" first="Edward G." last="Stopa">Edward G. Stopa</name></author><author><name sortKey="Song, Phillip C" sort="Song, Phillip C" uniqKey="Song P" first="Phillip C." last="Song">Phillip C. Song</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:038650BB0641AE4FE941295D723BFC7E3DA0ACFF</idno><date when="2016" year="2016">2016</date><idno type="doi">10.1002/lary.26065</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-Z8T1067S-K/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">002821</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">002821</idno><idno type="wicri:Area/Istex/Curation">002623</idno><idno type="wicri:Area/Istex/Checkpoint">000069</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000069</idno><idno type="wicri:doubleKey">0023-852X:2016:Chambers K:atrophy:of:the</idno><idno type="wicri:Area/Main/Merge">000090</idno><idno type="wicri:Area/Main/Curation">000090</idno><idno type="wicri:Area/Main/Exploration">000090</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">Atrophy of the tongue following complete versus partial hypoglossal nerve transection in a canine model</title><author><name sortKey="Chambers, Kyle J" sort="Chambers, Kyle J" uniqKey="Chambers K" first="Kyle J." last="Chambers">Kyle J. Chambers</name><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName><wicri:orgArea>Department of Otology and Laryngology, Harvard Medical School, Massachusetts</wicri:orgArea></affiliation></author><author><name sortKey="Anthony, Douglas C" sort="Anthony, Douglas C" uniqKey="Anthony D" first="Douglas C." last="Anthony">Douglas C. Anthony</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Rhode Island</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Lifespan Academic Medical Center and Brown University, Providence</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Lifespan Academic Medical Center and Brown University, Rhode Island, Providence</wicri:regionArea><wicri:noRegion>Providence</wicri:noRegion></affiliation></author><author><name sortKey="Randolph, Gregory W" sort="Randolph, Gregory W" uniqKey="Randolph G" first="Gregory W." last="Randolph">Gregory W. Randolph</name><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName><wicri:orgArea>Department of Otology and Laryngology, Harvard Medical School, Massachusetts</wicri:orgArea></affiliation></author><author><name sortKey="Hartnick, Christopher J" sort="Hartnick, Christopher J" uniqKey="Hartnick C" first="Christopher J." last="Hartnick">Christopher J. Hartnick</name><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName><wicri:orgArea>Department of Otology and Laryngology, Harvard Medical School, Massachusetts</wicri:orgArea></affiliation></author><author><name sortKey="Stopa, Edward G" sort="Stopa, Edward G" uniqKey="Stopa E" first="Edward G." last="Stopa">Edward G. Stopa</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Rhode Island</region></placeName><wicri:cityArea>Department of Pathology and Laboratory Medicine, Lifespan Academic Medical Center and Brown University, Providence</wicri:cityArea></affiliation><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, Lifespan Academic Medical Center and Brown University, Rhode Island, Providence</wicri:regionArea><wicri:noRegion>Providence</wicri:noRegion></affiliation></author><author><name sortKey="Song, Phillip C" sort="Song, Phillip C" uniqKey="Song P" first="Phillip C." last="Song">Phillip C. Song</name><affiliation wicri:level="3"><country>États-Unis</country><placeName><settlement type="city">Boston</settlement><region type="state">Massachusetts</region></placeName><wicri:orgArea>Department of Otology and Laryngology, Harvard Medical School, Massachusetts</wicri:orgArea></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Laryngoscope</title><title level="j" type="alt">THE LARYNGOSCOPE</title><idno type="ISSN">0023-852X</idno><idno type="eISSN">1531-4995</idno><imprint><biblScope unit="vol">126</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="2689">2689</biblScope><biblScope unit="page" to="2693">2693</biblScope><biblScope unit="page-count">5</biblScope><date type="published" when="2016-12">2016-12</date></imprint><idno type="ISSN">0023-852X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0023-852X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Anastomosis</term><term>Antimyosin heavy chain</term><term>Atrophy</term><term>Brown university</term><term>Canine</term><term>Canine model</term><term>Complete hypoglossal transection</term><term>Complete transection</term><term>Connective tissue</term><term>Denervated</term><term>Denervated side</term><term>Denervation</term><term>Donor nerve</term><term>Facial</term><term>Facial reanimation</term><term>Hypoglossal</term><term>Hypoglossal nerve</term><term>Hypoglossal nerve transection</term><term>Hypoglossal transection</term><term>Intravenous dose</term><term>Laboratory animal</term><term>Laryngeal</term><term>Laryngeal reinnervation</term><term>Laryngoscope</term><term>Less muscle area</term><term>Less severe</term><term>Looser connective tissue</term><term>Medial</term><term>Medial branch</term><term>Muscle atrophy</term><term>Muscle cell</term><term>Muscle fiber</term><term>Myosin</term><term>Myosin content</term><term>Nerve</term><term>Nerve anastomosis</term><term>Neuromuscular change</term><term>Neuromuscular organization</term><term>Nondenervated control side</term><term>Nondenervated side</term><term>Nonoperated side</term><term>Optical density</term><term>Otolaryngol head neck surg</term><term>Pale eosinophilia</term><term>Partial hypoglossal nerve transection</term><term>Partial transection</term><term>Rhode island</term><term>Right side</term><term>Severe atrophy</term><term>Tongue atrophy</term><term>Tongue dysfunction</term><term>Tongue function</term><term>Transection</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Objectives/Hypothesis: The hypoglossal nerve (XII) has been used as a donor nerve in facial and laryngeal reinnervation. The purpose of this study was to investigate the neuromuscular changes that occur within the tongue following partial or complete transection of XII using a canine model. Study Design: Histopathological comparison of tongue denervation following two types of XII resection in a canine model. Methods: Ten adult canines underwent complete unilateral resection of XII or resection of only the medial terminal branch of the hypoglossal nerve (mXII). After 6 months of recovery, tongue specimens were analyzed histopathologically using whole cross‐sections. Routine histologic sections were assessed by two neuropathologists blinded to the type of denervation. The cross‐sectional area was calculated of both sides of the tongue, and the amount of myosin was quantified morphometrically using immunohistochemistry for myosin (antimyosin heavy chain, fast isotype). Statistical comparison between partial and complete denervation was performed using the Student t test. Results: Six months following XII transection, quantitative measures of the cross‐sectional area of the tongue and content of myosin demonstrated severe muscle atrophy on the operated side of the tongue for both groups, compared to the nonoperated side. For partial transection involving only mXII, the degree of atrophy was less severe (P < .05). Conclusions: This study provides new histological information demonstrating that partial resection of the hypoglossal nerve, sacrificing only the proximal medial branch of the hypoglossal nerve (mXII), results in less severe atrophy of the tongue than complete transection of the entire hypoglossal nerve. Level of Evidence: NA Laryngoscope, 126:2689–2693, 2016</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Massachusetts</li><li>Rhode Island</li></region><settlement><li>Boston</li></settlement></list><tree><country name="États-Unis"><region name="Massachusetts"><name sortKey="Chambers, Kyle J" sort="Chambers, Kyle J" uniqKey="Chambers K" first="Kyle J." last="Chambers">Kyle J. Chambers</name></region><name sortKey="Anthony, Douglas C" sort="Anthony, Douglas C" uniqKey="Anthony D" first="Douglas C." last="Anthony">Douglas C. Anthony</name><name sortKey="Anthony, Douglas C" sort="Anthony, Douglas C" uniqKey="Anthony D" first="Douglas C." last="Anthony">Douglas C. Anthony</name><name sortKey="Hartnick, Christopher J" sort="Hartnick, Christopher J" uniqKey="Hartnick C" first="Christopher J." last="Hartnick">Christopher J. Hartnick</name><name sortKey="Randolph, Gregory W" sort="Randolph, Gregory W" uniqKey="Randolph G" first="Gregory W." last="Randolph">Gregory W. Randolph</name><name sortKey="Song, Phillip C" sort="Song, Phillip C" uniqKey="Song P" first="Phillip C." last="Song">Phillip C. Song</name><name sortKey="Song, Phillip C" sort="Song, Phillip C" uniqKey="Song P" first="Phillip C." last="Song">Phillip C. Song</name><name sortKey="Song, Phillip C" sort="Song, Phillip C" uniqKey="Song P" first="Phillip C." last="Song">Phillip C. Song</name><name sortKey="Stopa, Edward G" sort="Stopa, Edward G" uniqKey="Stopa E" first="Edward G." last="Stopa">Edward G. Stopa</name><name sortKey="Stopa, Edward G" sort="Stopa, Edward G" uniqKey="Stopa E" first="Edward G." last="Stopa">Edward G. Stopa</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/ChansonRoland/explor/ChansonRolandV6/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000090 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000090 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/ChansonRoland
|area= ChansonRolandV6
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:038650BB0641AE4FE941295D723BFC7E3DA0ACFF
|texte= Atrophy of the tongue following complete versus partial hypoglossal nerve transection in a canine model
}}
| This area was generated with Dilib version V0.6.38. |  |